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Ursodeoxycholic acid inhibits endothelin-1 production in human vascular endothelial cells

✍ Scribed by Ji Ma; Haruko Iida; Taisuke Jo; Haruhito Takano; Hitoshi Oonuma; Toshihiro Morita; Teruhiko Toyo-oka; Masao Omata; Ryozo Nagai; Yukichi Okuda; Nobuhiro Yamada; Toshiaki Nakajima

Book ID
113585131
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
396 KB
Volume
505
Category
Article
ISSN
0014-2999

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Endothelin-1 (ET-1) is a potent vasoconstrictor peptide synthesized and secreted by vascular endothelial cells. Regulation of ET-1 production occurs at the level of gene transcription. We previously demonstrated a role for arachidonic acid as an intracellular mediator in the regulation of gene expre