Ursodeoxycholic acid treatment of patients with primary biliary cirrhosis may lead to relief of pruritus and improvement of biochemical liver tests. The changes in serum and urinary bile acids induced by ursodeoxycholic acid treatment were studied. After 29 patients with primary biliary cirrhosis we
Ursodeoxycholic acid induces significant changes of plasma bile acids in primary biliary cirrhosis
✍ Scribed by Stiehl, A; Raedsch, R; Möller, B; Hopf, U; Lotterer, E; Fölsch, U; Bircher, J
- Book ID
- 123187970
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 67 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0168-8278
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Bile acid composition in fasting duodenal bile was assessed at entry and at 2 years in patients with primary biliary cirrhosis (PBC) enrolled in a randomized, doubleblind, placebo-controlled trial of ursodeoxycholic acid (UDCA) (10-12 mg/kg/d) taken as a single bedtime dose. Specimens were analyzed
We describe a detailed study of the effects of ursodeoxycholic acid administration on bile acid composition of the serum and bile of patients with primary biliary cirrhosis. Gas chromatography-mass spectrometry was used to analyze bile acids from 10 patients with primary biliary cirrhosis before and
We have compared the effect of ursodeoxycholic acid with placebo on the clinical state, blood liver chemistries and serum and urinary bile acids in four patients with primary biliary cirrhosis. All parameters were evaluated monthly, and bile acid composition was measured by capillary gas-liquid chro