Previous studies from our groups have demonstrated improvements in biochemical markers of liver function when cystic fibrosis patients with associated liver disease were administered oral ursodeoxycholic acid. The magnitude of the response was somewhat less than that found when comparable doses (10
Ursodeoxycholic acid in cystic fibrosis-associated liver disease
β Scribed by Chee Y. Ooi; Scott Nightingale; Peter R. Durie; Steven D. Freedman
- Book ID
- 116619716
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 80 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1569-1993
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π SIMILAR VOLUMES
The efficacy of 2 years of treatment with ursodeoxycholic acid (UDCA) in cystic fibrosis (CF)-associated liver disease was evaluated by liver biopsies and liver function tests in 10 patients aged 8 to 28 years. The metabolism of UDCA was investigated by analysis of urinary bile acids with fast atom
We have previously documented that ursodeoxycholic acid exerts a beneficial effect on liver function and bile acid metabolism in patients with cystic fi- brosis. We hypothesized that the mechanism of action may be related in part to the choleretic properties of the administered bile acid. We therefo
AND THE ITALIAN GROUP FOR THE STUDY OF URSODEOXYCHOLIC ACID IN CYSTIC FIBROSIS\* ment. Thus, we concluded that UDCA administration im-Liver disease is increasingly recognized as a major proves clinical and biochemical parameters in CF pacause of morbidity in cystic fibrosis (CF). Preliminary tients