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Ursodeoxycholic acid in cystic fibrosis-associated liver disease

✍ Scribed by Chee Y. Ooi; Scott Nightingale; Peter R. Durie; Steven D. Freedman


Book ID
116619716
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
80 KB
Volume
11
Category
Article
ISSN
1569-1993

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The efficacy of 2 years of treatment with ursodeoxycholic acid (UDCA) in cystic fibrosis (CF)-associated liver disease was evaluated by liver biopsies and liver function tests in 10 patients aged 8 to 28 years. The metabolism of UDCA was investigated by analysis of urinary bile acids with fast atom

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We have previously documented that ursodeoxycholic acid exerts a beneficial effect on liver function and bile acid metabolism in patients with cystic fi- brosis. We hypothesized that the mechanism of action may be related in part to the choleretic properties of the administered bile acid. We therefo

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AND THE ITALIAN GROUP FOR THE STUDY OF URSODEOXYCHOLIC ACID IN CYSTIC FIBROSIS\* ment. Thus, we concluded that UDCA administration im-Liver disease is increasingly recognized as a major proves clinical and biochemical parameters in CF pacause of morbidity in cystic fibrosis (CF). Preliminary tients