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Ursodeoxycholic acid in cholestasis: Potential mechanisms of action and therapeutic applications

โœ Scribed by Ulrich Beuers; James L. Boyer; Gustav Paumgartner

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
74 KB
Volume
28
Category
Article
ISSN
0270-9139

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โœฆ Synopsis

The dihydroxy bile acid, ursodeoxycholic acid (UDCA), is increasingly used for the treatment of chronic cholestatic liver diseases. First reports of a beneficial effect on serum liver tests in cholestatic disorders were published in the 1980s in the Western literature, 1-3 but similar observations had been made previously in Japan. 4,5 Today, the therapeutic efficacy of UDCA has been shown for only one cholestatic disorder, primary biliary cirrhosis (PBC). 6 The mechanism of action of UDCA in cholestasis has also not yet been clearly identified. Therefore, the aim of this article is to summarize clinical and experimental work that may help to clarify possible mechanisms of action of UDCA in cholestasis and provide a clearer rationale for the administration of UDCA in special cholestatic disorders.

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