Ursodeoxycholic acid improves the hepatic metabolism of essential fatty acids and retinol in children with cystic fibrosis
✍ Scribed by Guy Lepage; Khazal Paradis; Florence Lacaille; Lyne Sénéchal; Nancy Ronco; Josée Champagne; Catherine Lenaerts; Claude C. Roy; Andrée Rasquin-Weber
- Book ID
- 117165796
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 690 KB
- Volume
- 130
- Category
- Article
- ISSN
- 1097-6833
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Twenty-one pre-adolescent cystic fibrosis (CF) children with good clinical scores had significant (P < 0.001) deficiencies of arachidonic (mean 3.8% of total plasma fatty acids + SD 1.4) and linoleic (18.1 + 6.3) acids compared with controls (6.0 + 1.0, and 27.6 + 3.9, respectively). Despite the pre
We have previously documented that ursodeoxycholic acid exerts a beneficial effect on liver function and bile acid metabolism in patients with cystic fi- brosis. We hypothesized that the mechanism of action may be related in part to the choleretic properties of the administered bile acid. We therefo