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Ursodeoxycholic acid for symptomatic primary biliary cirrhosis: Preliminary analysis of a double-blind multicenter trial

✍ Scribed by P.M. Battezzati; M. Podda; F.B. Bianchi; R. Naccarato; F. Orlandi; C. Surrenti; L. Pagliaro; F. Manenti

Book ID
118566199
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
578 KB
Volume
17
Category
Article
ISSN
0168-8278

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Ursodeoxycholic acid, a dihydroxyl bile acid normally present in human beings in minimal amounts, becomes incorporated into the bile salt pool when taken orally. In cholestasis, bile acids are retained in the liver and are hepatotoxic. Ursodeoxycholic acid is the least-known hepatotoxic bile acid, h

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One hundred fifty-one patients with primary biliary cirrhosis (PBC) grouped into four strata based on entry serum bilirubin (<2 mg/dL vs. 2 mg/dL or greater) and liver histology (stages I, 1 1 vs. stages 111, IV-Ludwig criteria) were randomized within each stratum to ursodiol or placebo given in a s