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Ursodeoxycholic acid-dependent activation of the glucocorticoid receptor

✍ Scribed by Hirotoshi Tanaka; Isao Makino

Book ID
115765175
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
874 KB
Volume
188
Category
Article
ISSN
0006-291X

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## Abstract A crucial step in the interaction of glucocorticoids with target cells is the activation step, which involves a conformational change in the cytoplasmic glucocorticoid–receptor protein complexes and facilitates their binding to the cell nucleus. Activation can be quantified by measuring