We have compared the effect of ursodeoxycholic acid with placebo on the clinical state, blood liver chemistries and serum and urinary bile acids in four patients with primary biliary cirrhosis. All parameters were evaluated monthly, and bile acid composition was measured by capillary gas-liquid chro
Ursodeoxycholic acid administration on bile acid metabolism in patients with early stages of primary biliary cirrhosis
β Scribed by Giuseppe Mazzella; Paolo Parini; Franco Bazzoli; Nicola Villanova; Davide Festi; Rita Aldini; Aldo Roda; Antonio Cipolla; Carla Polimeni; Domenica Tonelli; Enrico Roda
- Book ID
- 112508822
- Publisher
- Springer US
- Year
- 1993
- Tongue
- English
- Weight
- 587 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0163-2116
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Bile acid composition in fasting duodenal bile was assessed at entry and at 2 years in patients with primary biliary cirrhosis (PBC) enrolled in a randomized, doubleblind, placebo-controlled trial of ursodeoxycholic acid (UDCA) (10-12 mg/kg/d) taken as a single bedtime dose. Specimens were analyzed
We describe a detailed study of the effects of ursodeoxycholic acid administration on bile acid composition of the serum and bile of patients with primary biliary cirrhosis. Gas chromatography-mass spectrometry was used to analyze bile acids from 10 patients with primary biliary cirrhosis before and
Ursodeoxycholic acid treatment of patients with primary biliary cirrhosis may lead to relief of pruritus and improvement of biochemical liver tests. The changes in serum and urinary bile acids induced by ursodeoxycholic acid treatment were studied. After 29 patients with primary biliary cirrhosis we