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Uroporphyrinogen oxidation catalyzed by reconstituted cytochrome P450IA2

โœ Scribed by Richard W. Lambrecht; Peter R. Sinclair; Nadia Gorman; Jacqueline F. Sinclair

Book ID
115709346
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
856 KB
Volume
294
Category
Article
ISSN
0003-9861

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The oxidation of uroporphyrinogen, an intermediate of the heme biosynthetic pathway, by methylcholanthrene-inducible isozyme(s) of cytochrome P-450 has been proposed to play a role in the development of chemically induced uroporphyria. Prior work from this laboratory [lo] indicated that although add