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Uroporphyria caused by ethanol in Hfe(−/−) mice as a model for porphyria cutanea tarda

✍ Scribed by Peter R. Sinclair; Nadia Gorman; Heidi W. Trask; William J. Bement; Juliana G. Szakacs; George H. Elder; Dominic Balestra; Jacqueline F. Sinclair; Glenn S. Gerhard


Book ID
111722102
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
205 KB
Volume
37
Category
Article
ISSN
0270-9139

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Effect of iron and ascorbate on uroporph
✍ Nadia Gorman; Adrian Zaharia; Heidi S. Trask; Juliana G. Szakacs; Nicholas J. Ja 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 625 KB

Excess hepatic iron is known to enhance both porphyria cutanea tarda (PCT) and experimental uroporphyria. Since previous studies have suggested a role for ascorbate (AA) in suppressing uroporphyria in AA-requiring rats (in the absence of excess iron), the present study investigated whether AA could