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Urokinase-type plasminogen activator gene therapy in liver cirrhosis is mediated by activation of metalloproteinase and down-regulation of collagens gene expression: Juan Armendariz-Borunda, University of Guadalajara, Guadalajara, Jal. Mexico; Miriam Bueno, Silvia Salgado, Vidal Delgado, University of Guadalajara, Guadalajara Mexico; Estuardo Aguilar-Cordova, Harvard Gene Therapy Initiative, Boston, MA

Book ID
118689207
Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
215 KB
Volume
34
Category
Article
ISSN
0270-9139

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## Abstract Human urokinase‐type plasminogen activator (uPA) gene administration via an adenoviral (Ad)‐vector induced cirrhosis regression and ameliorated hepatic dysfunction in a model of experimental liver cirrhosis. The administration of a single dose of 6 × 10^11^ viral particles per kilogram