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Urokinase-Type Plasminogen Activator Deficiency Promotes Colitis-Associated Carcinogenesis in Mice

✍ Scribed by E. Karamanavi; K. Angelopoulou; S. Lavrentiadou; A. Tsingotjidou; Z. Abas; I. Taitzoglou; I. Vlemmas; S. Erdman; T. Poutahidis


Book ID
113696137
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
67 KB
Volume
146
Category
Article
ISSN
0021-9975

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## Abstract The urokinase plasminogen activator receptor (uPAR) regulates macrophage adhesion and migration by binding directly to matrix proteins and signaling through integrin complexes. In this study, we examined the role of uPAR on macrophage infiltration into the vascular wall. Stable murine m