Urokinase-type plasminogen activator and malignancy
โ Scribed by M.J. Duffy
- Book ID
- 119154318
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 996 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0268-9499
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๐ SIMILAR VOLUMES
Elevated levels of expression of the urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 have shown to be related to poor prognosis in a variety of cancer types. In the present study, cytosolic levels of uPA and PAI-1 were determined with enzyme-linked immunosorbent assays in cytosols
Urokinase plasminogen activator (uPA) is a serine protease involved in cancer invasion and metastasis. uPA mediates its action while attached to a membrane-bound receptor (uPAR). In this investigation we show that uPAR levels correlate with uPA levels in human breast cancers. uPAR levels, however, d