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Urokinase stimulates differentiation of fibroblasts into myofibroblasts and their proliferation in damaged adventitia

✍ Scribed by O. S. Plekhanova; E. A. Volynskaya; N. I. Kalinina; E. V. Parfenova


Book ID
105575675
Publisher
Springer US
Year
2000
Tongue
English
Weight
921 KB
Volume
129
Category
Article
ISSN
0007-4888

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## Abstract Lung fibroblast proliferation and differentiation into myofibroblasts are pathological key events during development of lung fibrosis. Cyclic nucleotide signaling is described as a negative modulator of these cellular processes, and cyclic nucleotide degrading type 4 phosphodiesterases