## Abstract There is a strong correlation between the overexpression of urokinase‐type plasminogen activator receptor (uPAR) and gastric cancer invasion. This study examined the effect of phospholipid lysophosphatidic acid (LPA) on uPAR expression in human gastric cancer AGS cells and the underlyin
Urokinase plasminogen activator receptor on invasive cancer cells: A prognostic factor in distal gastric adenocarcinoma
✍ Scribed by Warner Alpízar-Alpízar; Ib Jarle Christensen; Eric Santoni-Rugiu; Arne Skarstein; Kjell Ovrebo; Martin Illemann; Ole Didrik Laerum
- Book ID
- 112101587
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- French
- Weight
- 423 KB
- Volume
- 131
- Category
- Article
- ISSN
- 0020-7136
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## Abstract Gastric cancer is the second cancer causing death worldwide. Both incidence and mortality rates vary according to geographical regions. The receptor for urokinase plasminogen activator (uPAR) is involved in extracellular matrix degradation by mediating cell surface associated plasminoge
The expression of urokinase-type plasminogen activator (u-PA), its receptor (u-PAR) and metalloproteases activity were analyzed in 4 human gastric-cancer cell lines (AGS, Hs746T, SNU-1, and SNU-5), in an attempt to relate these activities to their invasive potential and tumorigenicity on the modifie