## Abstract Vascular smooth‐muscle cell (VSMC) proliferation plays a vital role in hypertension, atherosclerosis and restenosis. It has been reported that emodin, an active component extracted from rhubarb, can stop the growth of cancer cells; however, it is not known if emodin exerts similar anti‐
✦ LIBER ✦
Urokinase plasminogen activator induces human smooth muscle cell migration and proliferation via distinct receptor-dependent and proteolysis-dependent mechanisms
✍ Scribed by Victoria Stepanova; Svetlana Mukhina; Eleonore Köhler; Thérese J. Resink; Paul Erne; Vsevolod A. Tkachuk
- Book ID
- 110244181
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 110 KB
- Volume
- 195
- Category
- Article
- ISSN
- 0300-8177
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## Abstract Transforming growth factor‐β1 (TGF‐β1) stimulates expression of plasminogen activator inhibitor type‐1 (PAI‐1), a serine protease inhibitor (__SERPIN__) important in the control of stromal barrier proteolysis and cell‐to‐matrix adhesion. Pharmacologic agents that target MEK (PD98059, U0