Urine-TPA (Tissue Polypeptide Antigen), flowcytometry and cytology as markers for tumor invasiveness in urinary bladder carcinoma
✍ Scribed by Carbin, B.-E. ;Ekman, P. ;Eneroth, P. ;Nilsson, B.
- Book ID
- 104690181
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 354 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0300-5623
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✦ Synopsis
Urine-Tissue Polypeptide Antigen (U-TPA) was measured in 81 patients with a previously diagnosed bladder carcinoma. U-TPA was elevated in 74% of the patients with invasive bladder cancer as compared to only 15% of the patients with superficial tumors. Only one patient without a tumor recurrence had an elevated U-TPA level (4%). The results were compared with cytological grading and flow-DNA measurements in a multivariate analysis with T-category as the result variable. U-TPA and grade showed each, independently, a significant relation (P much less than 0.001) to T-category whereas the result of the DNA measurements did not explain the variation in T-category when U-TPA and grade were already in the equation. For diagnostic purposes U-TPA seems to be of limited value but may serve as an indicator of tumor recurrence in bladder cancer patients.