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Urine proteomic profiling for biomarkers of acetaminophen-induced acute liver injury in mice and humans

✍ Scribed by Rachel P.L. van Swelm; Coby M.M. Laarakkers; Rosalinde Masereeuw; Frans G.M. Russel


Book ID
113934083
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
65 KB
Volume
290
Category
Article
ISSN
0300-483X

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In studies designed to simulate a clinical observation in which an individual became tolerant to normally lethal doses of acetaminophen (APAP), mice were pretreated with increasing doses of APAP for 8 days and challenged on day 9 with normally supralethal doses of APAP. These animals developed minim