Urinary α1-microglobulin as an indicator protein of renal tubular dysfunction caused by environmental cadmium exposure
✍ Scribed by Chiharu Tohyama; Etsuko Kobayashi; Hiroshi Saiko; Naoko Sugihara; Atsuhiro Nakano; Yuko Mitane
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 690 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0260-437X
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✦ Synopsis
An epidemiologic investigation was carried out to clarify the significance of the urinary excretion of a,microglobulin ( a , -M G ) in people aged 50 years and over living in a Cd-polluted area in Japan. Approximately 80% of the population participated in the health examination. The urinary and serum levels and the relative clearance of a , -M G to creatinine clearance were compared with various parameters (age, urinary microglo globulin (&-MG), total protein, Cd, Cu and Zn, serum B2-MG, creatinine and blood urea nitrogen and relative clearances of a,-MG, &MG, inorganic phosphate and uric acid). It was found that the urinary excretion of a,-MG is closely associated with the urinary Cd and Cu and with the indices of renal dysfunction listed above. These results suggest that the urinary a , -M G level markedly reflects a degree of proximal tubular dysfunction and that it may be useful as one of the screening measures for proximal tubular dysfunction caused by environmental Cd exposure.