Urinary steroid patterns after short and long term treatment with human chorionic gonadotropin (HCG) of prepubertal boys with undescended testes
✍ Scribed by Teller, Walter M. ;Ferlemann, Martin
- Publisher
- Springer-Verlag
- Year
- 1973
- Weight
- 371 KB
- Volume
- 114
- Category
- Article
- ISSN
- 0044-2917
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✦ Synopsis
Fourteen prepubertM boys (aged 5--14 years) with either unilateral or bilateral undescended testes and 2 males (aged 17 and 18 years) with hypopituitarism received human ehorionie gonadotropin (HCG) either in high doses for a short (3 day) period (6 subjects) or in low doses for a long (2---6 week) period (10 subjects). Before and after HCG administration three ll-deoxy C1~, four ll-oxy C1~ and three C~1 steroids were individually determined in 24-hour-urines by previously described paper chromatographic eolorimetrie techniques. After both short and long term treatment with HCG the following changes of urinary steroid patterns occurred: a) increase of C1902/C190~, b) increase of percentage of allotetrahydrocortisol, e) decrease of total tetrahydrated C~1 steroids. In addition, long term application of HCG resulted in d) increase of 5a/Sfl of ll-deoxy C19 (C1~O2) and 11-oxy C19 (ClaOa) steroids, and e) increase of dehydroepiandrosterone. The effects of HCG an steroid metabolism and urinary excretion patterns can be interpreted as being caused by androgens which are produced by the testes during gonadotropie stimulation.