Urinary platinum in hospital personnel occupationally exposed to platinum-containing antineoplastic drugs

✍ Scribed by Angela S. Ensslin; Angelika Pethran; Rudolf Schierl; Günter Fruhmann

• Book ID: 104760275
• Publisher: Springer-Verlag
• Year: 1994
• Tongue: English
• Weight: 350 KB
• Volume: 65
• Category: Article
• ISSN: 0340-0131
• DOI: 10.1007/bf00405699

✦ Synopsis

Urinary platinum levels of 21 nurses and hospital pharmacy personnel occupationally exposed to platinum containing antineoplastic drugs were determined in 24-h urine by voltammetric analysis after UV photolysis. All study participants applied standard safety measures, including a vertical laminar air-flow cabinet and latex gloves The amount of platinum-containing drugs prepared for intravenous application ranged from 40-3260 mg/day Urinary platinum was detected in 9 of 52 urine samples collected on days when platinum-containing drugs were mixed (limit of determination 4 ng/l) In comparison with a non-exposed control group, elevated urinary platinum levels were found in one pharmacist ( 35 ng/g creatinine) and one pharmacy technician ( 28 ng/g creatinine) The pharmacist's urinary plantinum remained elevated after 2 days without occupational exposure to antineoplastic drugs The urinary platinum level of the pharmacy technician dropped considerably after several weeks without handling cytostatic drugs Voltammetric detection of urinary platinum is a highly sensitive method suitable for biological and environmental monitoring.