𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Urinary pepsinogen isozymes: A highly polymorphic locus in man

✍ Scribed by R. T. Taggart; R. C. Karn; A. D. Merritt; P. L. Yu; P. M. Conneally

Book ID
104695642
Publisher
Springer
Year
1979
Tongue
English
Weight
774 KB
Volume
52
Category
Article
ISSN
0340-6717

No coin nor oath required. For personal study only.

✦ Synopsis

A genetic analysis of human urinary pepsinogen isozymes is presented. Nine discrete phenotypes were identified in a population survey of 215 unrelated Caucasian individuals. The phenotypes were characterized by differences among the staining intensities of the activated group I pepsinogens, Pg 5, Pg 4, Pg 3, and Pg 2. The genetic studies demonstrated that the codominant expression of four alleles, PgA, PgB, PgC and PgD, at a single genetic locus determined the nine phenotypes identified. Linkage analysis excluded close linkage of the Pg locus with the chromosome 6 markers HLA, GLO1, and Bf.

πŸ“œ SIMILAR VOLUMES

Urinary glucuronide excretion of fenofib
Urinary glucuronide excretion of fenofibric and clofibric acid glucuronides in man. Is it polymorphic?
✍ H. F. Liu; M. Vincent-Viry; M. M. Galteau; R. GuΓ©guen; J. Magdalou; A. Nicolas; πŸ“‚ Article πŸ“… 1991 πŸ› Springer 🌐 English βš– 780 KB

The possible polymorphism of the glucuronidation reaction in man has been investigated using two hypolipidaemic compounds, fenofibrate and clofibrate, as the test probes. The formation of fenofibryl and clofibryl glucuronides was identified by their susceptibility to hydrolyses by beta-glucuronidase