Urinary isoprostanes in Friedreich ataxia: Lack of correlation with disease features

✍ Scribed by Lauren M. Myers; David R. Lynch; Jennifer M. Farmer; Lisa S. Friedman; John A. Lawson; Robert B. Wilson

• Book ID: 102945210
• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 540 KB
• Volume: 23
• Category: Article
• ISSN: 0885-3185
• DOI: 10.1002/mds.22038

✦ Synopsis

Abstract

To assess the utility of urinary isoprostanes as markers of oxidative injury in Friedreich ataxia (FA), we compared levels of urinary F~2~‐isoprostanes in patients with FA and healthy control subjects. Levels of urinary F~2~‐isoprostanes in FA patients were not different from controls and were not significantly associated with age, GAA repeat length, disability level, or the use of antioxidants. Thus, urinary F~2~‐isoprostanes are not a useful biomarker in FA. © 2008 Movement Disorder Society.