Urinary homovanillic acid and vanillylmandelic acid in workers exposed to carbon disulfide

✍ Scribed by X. F. Yang; B. L. Lee; A. L. New; H. Y. Ong; L. Ma; Q. Zhang; C. N. Ong

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 498 KB
• Volume: 29
• Category: Article
• ISSN: 0271-3586
• DOI: 10.1002/(sici)1097-0274(199603)29:3<269::aid-ajim6>3.0.co;2-l

✦ Synopsis

Homovanillic acid (HVA) and ~~anill~liiiandellic acid (VMA), two end products of dopaniine metabolism, were measured in 60 workers exposed to carbori disulfide (CS,) in a rayon juctory and in 48 une.xposed workers. The airborne CS, concentrations in eight major exposure zones of the plant were measured monthly over a period of 4 years, from 1990 to 1994. In addition, the exposure coricei~trutions and exposure history of each worker were integrated to estiniute the overall lifetime exposure. Industrial hygiene data showed that the geometric meuit concentrations .fCS, in the plant runged,fiom 2.68 to 20. I 9 ppm, arid more than 15% of the studied populution hud been repeatedly exposed to CS, at concentrations exceeding the ACGIH recommended time-weighted curerage of 10 ppm. The results shorcvd that there M'US (I .siRnifcuntly lo\t*er leisel and a higher proportion of' CS, workers with decreased HVA und VMA excretion. However, there were no stutisticnl correlations between the two dopaminergic metabolites and the meun CS, concentrution, and years of employment. In contrast, signifcant dose-effect relationships were obsenvd betrrven these ficw metabolites and the integrated cumulative exposure (ICE) variable. The correlation coeflicients for ICE and HVA, und ICE nnd VMA were -0.35 ( p < 0.01) and -0.20 ( p < 0.05), respectively. These duta siiggest thut chronic exposure to CS, was associated with measurable redi~tion in catecholamine tnetabolite concentrations. This finding is compatible with the earlier obsenutioris in laboratory animals that CS, exposures interfere with neurochemical metabolism. 0 1906 IVilc,y-Liss. h.