Urinary excretion of urodilatin in patients with cirrhosis

✍ Scribed by J Salo; W Jimenez; M Kuhn; A Gines; P Gines; G Fernandez-Esparrach; P Angeli; J Claria; R Bataller; V Arroyo; W Forssmann; J Rodes

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 181 KB
• Volume: 24
• Category: Article
• ISSN: 0270-9139
• DOI: 10.1002/hep.510240621

✦ Synopsis

This investigation includes 36 patients (24 men, 12 women; age: 55 { 2 years; means { SE) with cirrhosis and 21 normal subjects

The family of natriuretic peptides includes a series of at (13 men, 8 women, age: 56 { 1). The etiology of cirrhosis was alcoholic least four different substances: atrial natriuretic peptide in 13 cases (all of them had been abstinent for a period of at least 6 (ANP), brain natriuretic peptide (BNP), C-natriuretic peptide months before the study), anti-HCV-positive in 16, HBsAg-positive (CNP), and urodilatin, with similar amino acid sequence and in 5, and cryptogenic in the remaining 2 cases. The diagnosis of cirrhosis was based on liver histology (27 cases) or on clinical, biochemical, and exploratory data. Thirteen patients had neither history of sodium retention nor ascites, as assessed by ultrasonography, Abbreviations: ANP, atrial natriuretic peptide; BNP, brain natriuretic peptide; CNP, C-or edema at the time of study. The remaining 23 patients had modernatriuretic peptide; NE, norepinephrine; PRA, plasma renin activity; HPLC, high-perforate or severe ascites, which was confirmed by diagnostic paracentesis mance liquid chromatography. in all cases. Seven patients with ascites had functional renal failure From the