Urinary excretion of hippuric acid andm-methylhippuric acid after administration of toluene andm-xylene mixture to rats

✍ Scribed by M. Ogata; T. Fujii

• Publisher: Springer-Verlag
• Year: 1979
• Tongue: English
• Weight: 278 KB
• Volume: 43
• Category: Article
• ISSN: 0340-0131
• DOI: 10.1007/bf00454279

✦ Synopsis

Male Wistar rats were injected intraperitoneally (i p ) with toluene alone, m-xylene alone, and in combination with both of them Urinary excretion of hippuric acid or m-methylhippuric acid of rats injected with solvents of various concentrations was investigated from the end of the injections up to 48 h later, at appropriate intervals The amounts of increased excretion of HA and m-MHA in 0-24 h urine samples of the rats given simultaneous injections of toluene and m-xylene were not lower than those of the rats given single injections of toluene alone or m-xylene alone, in the same amount Data indicated that simultaneous administration of toluene and m-xylene did not significantly interfere with the metabolism of toluene or m-xylene.