Urinary excretion of amitriptyline N-oxide in humans

✍ Scribed by Giuseppe Santagostino; Roberto Maffei Facino; Demetrio Pirillo

• Publisher: John Wiley and Sons
• Year: 1974
• Tongue: English
• Weight: 357 KB
• Volume: 63
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600631104

✦ Synopsis

The excretion rate of amitriptyline N-oxide was measured in healthy human subjects after the administration of a single oral dose of amitriptyline. The total amount of this metabolite excreted accounted for about 1% of the dose. It appears in the urine soon after administration of the parent compound but has practically disappeared by the 9th h? after treatment. The role of this metabolite in amitriptyline degradation in humans is discussed.

Keyphrases 0 Amitriptyline-excretion of N-oxide urinary metabolite in humans 0 Metabolism-urinary excretion of amitriptyline N-oxide in humans 0 Biotransformation-urinary excretion of amitriptyline N-oxide in humans ' All chemicals and reagents (analytical grade) were obtained from Merck, Darmstadt, Germany. Amitriptyline, nortriptyline, desmethylnortriptyline, 10-hydroxyarnitriptyline, and 10-hydroxynortriptyline were supplied by Merck, Sharp & Dohme,