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Urinary Elimination of Nitrazepam and its Main Metabolites

✍ Scribed by Kangas, L.

Book ID
114799638
Publisher
Wiley (Blackwell Publishing)
Year
2009
Weight
259 KB
Volume
45
Category
Article
ISSN
0001-6683

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## Abstract Sulfamethoxazole was labelled at positions 3, 5, and 4β€² by H/D exchange in a mixture of 5% ^2^H~2~SO~4~ and 95% ^2^H~2~O (v/v) under reflux for 72h with good isotope incorporation and acceptable yield. Subsequently, [^2^H~3~]‐sulfamethoxazole‐__N__~1~‐glucuronide and [^2^H~3~]‐__N__~4~‐