✦ LIBER ✦

Urinary cyclic AMP response to bovine parathyroid hormone during treatment with neuroleptics

✍ Scribed by Derek G. Waller; Janet D. M. Albano; J. Guyedwards

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 206 KB
Volume: 2
Category: Article
ISSN: 0885-6222
DOI: 10.1002/hup.470020205

No coin nor oath required. For personal study only.

✦ Synopsis

The urinary cyclic AMP response to bovine parathyroid hormone and urinary concentrating ability (max Uosm) after des-amino-o-arginine vasopressin were studied in nine volunteers and seven patients receiving long-term neuroleptic treatment. Max Uosm was lower in the patient group (770 k 70 mosmol/kg) compared with the controls (948 -t 152 mosmol/kg) but the trend to a lower cAMP response to bovine PTH was not statistically significant. These results suggest that, although adenylate cyclase inhibition may contribute, other mechanisms are also important in the genesis of reduced urine concentrating ability in patients treated with psychotropic drugs.

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