✍ Scribed by Thomas C. Gasser; Erik H. Larsen; Douglas M. England; Peder H. Graversen; Torben Dørflinger; Paul O. Madsen; Reginald C. Bruskewitz
No coin nor oath required. For personal study only.
In an earlier study, urinary bladder regeneration was investigated. For that purpose, 15 dogs were subjected to total or subtotal cystectomy, and a silicone rubber prosthesis was nestled in the trigone and covered with polyglycolic acid mesh. After 3-5 months, a newly formed urinary reservoir was found in six dogs. Since transitional cell epithelium and smooth muscle were identified in the wall of the reservoir, it was concluded that bladder regeneration had probably occurred. However, the possibility of distention of the trigone to form the new cavity could not be ruled out.
Therefore, six additional dogs were subjected to subtotal cystectomy, ileal loop, and temporary artificial bladder implantation. The edges of the bladder resection were marked with nonabsorbable sutures. In three fully evaluable dogs a urinary cavity was identified. This was mainly formed by trigonal distention. While the epithelium had regrown over a small area of fibrous tissue found at the dome of the reservoir, no smooth muscle regeneration was found.
It is concluded that the new reservoir was formed by trigonal dilatation rather than by regeneration.
📜 SIMILAR VOLUMES
A temporary artificial bladder was implanted in 15 female dogs undergoing total or subtotal cystectomy. One or two months after implantation, the prosthesis was removed. In three dogs sacrificed 6 months after prosthesis implantation, a new urinary reservoir was identified. Two dogs failed to develo