✦ LIBER ✦
Urinary and faecal excretion of chrysene and chrysene metabolites by rats after oral, intraperitoneal, intratracheal or intrapulmonary application
✍ Scribed by G. Grimmer; H. Brune; G. Dettbarn; U. Heinrich; J. Jacob; E. Mohtashamipur; K. Norpoth; F. Pott; R. Wenzel-Hartung
- Publisher
- Springer-Verlag
- Year
- 1988
- Tongue
- English
- Weight
- 502 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0340-5761
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✦ Synopsis
The urinary and faecal excretion of chrysene and its phenolic metabolites after oral, intraperitoneal, intratracheal, and intrapulmonary administration to rats have been studied by means of gas chromatography/mass spectrometry. The metabolite profile was found to depend on the mode of excretion and on the route of administration. In all cases the oxidation of chrysene in the 1,2- or 3,4-position predominates, whereas oxidation in the 5,6-position (K-region) seems be a minor pathway.