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Urinary 7α-hydroxy-3-oxochol-4-en-24-oic and 3-oxochola-4,6-dien-24-oic acids in infants with cholestasis

✍ Scribed by Akihiko Kimura; Mikako Suzuki; Tsuyoshi Murai; Takao Kurosawa; Masahiko Tohma; Michio Sata; Toshiro Inoue; Atsuo Hoshiyama; Eisuke Nakashima; Yasuhiro Yamashita; Takuji Fujisawa; Hirohisa Kato

Book ID
119135776
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
129 KB
Volume
28
Category
Article
ISSN
0168-8278

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Accumulation of 7α-hydroxy-4-cholesten-3
Accumulation of 7α-hydroxy-4-cholesten-3-one and cholesta-4,6-dien-3-one in patients with cerebrotendinous xanthomatosis: Effect of treatment with chenodeoxycholic acid
✍ Ingemar Björkhem; Sverre Skrede; Marie S. Buchmann; Cara East; Scott Grundy 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 580 KB

Evidence was recently presented that an essential part of the accumulation of cholestanol in patients with cerebrotendinous xanthomatosis is due to acceleration of a novel pathway, involving ?a-hydroxylated intermediates in bile acid biosynthesis as precursors (J. Clin. Invest. 1986; 75:448-456). Su