✦ LIBER ✦

Urinary 6β-hydroxycortisol excretion in Hong Kong Chinese patients with hepatocellular carcinoma and other chronic liver diseases

✍ Scribed by Maggie C. Y. Ng; Robert P. Young; Julian A. J. H. Critchley; Nancy W. Y. Leung; Joseph W. Y. Lau; Arthur K. C. Li

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 612 KB
Volume: 77
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19960415)77:8<1427::aid-cncr2>3.0.co;2-9

No coin nor oath required. For personal study only.

✦ Synopsis

The biotransformation of xenobiotics into toxic metabolites by cytochrome P-450 has been implicated in carcinogenesis. This study investigated CYP3A4 activity, which metabolically activates procarcinogens such as aflatoxin B,, by measuring the urinary 6P-hydroxycortisol(6~OHF) to free cortisol (F) ratio in patients with hepatocellular carcinoma (HCC) and other chronic liver diseases.