Uridine-induced hypothermia in mice and rats in relation to plasma and tissue levels of uridine and its metabolites
β Scribed by G. J. Peters; C. J. Groeningen; E. J. Laurensse; J. Lankelma; A. Leyva; H. M. Pinedo
- Book ID
- 104690025
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 20 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0344-5704
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π SIMILAR VOLUMES
Serum and plasma uridine levels in mice, rats, and humans were conveniently measured by reverse-phase high-pressure liquid chromatography. Human serum levels were in the range of 1.9 to 8.4 nmoliml. rat serum levels ranged from 3.7 to 9.4 nmoliml, and mouse serum levels measured 8.0 to 11.8 nmoliml.
## Abstract The sensitivity of different wildβtype and 5βazacytidineβresistant lines of AKR leukemic mice to 5βazacytidine varies in relation to the activity of uridine kinase isolated from corresponding leukemic livers. The enhancement of liver uridine kinase activity observed in leukemic mice fol