Urethane increases reactive oxygen species and activates extracellular signal-regulated kinase in RAW 264.7 macrophages and A549 lung epithelial cells

Protein kinase C-ERK1/2 signal pathway s

Protein kinase C-ERK1/2 signal pathway switches glucose depletion-induced necrosis to apoptosis by regulating superoxide dismutases and suppressing reactive oxygen species production in A549 lung cancer cells

✍ Cho Hee Kim; Song Iy Han; Su Yeon Lee; Hyun Suk Youk; Ji Young Moon; Hong Quan D 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 832 KB

## Abstract Cells typically die by either apoptosis or necrosis. However, the consequences of apoptosis and necrosis are quite different for a whole organism. In the case of apoptosis, the cell content remains packed in the apoptotic bodies that are removed by marcrophages, and thereby inflammation