UREA-RESISTANT NEUTROPHIL ALKALINE PHOSPHATASE IN MOTHERS WITH TRISOMY 21 PREGNANCY
β Scribed by Grozdea, J.; Vergnes, H.; Martin, J.
- Book ID
- 122851812
- Publisher
- The Lancet
- Year
- 1983
- Tongue
- English
- Weight
- 292 KB
- Volume
- 322
- Category
- Article
- ISSN
- 0140-6736
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Activity levels of total and placental alkaline phosphatase (AP) were determined in maternal serum and neutrophils of normal and Down syndrome pregnancies. The placental iso-enzyme (PAP) was identified by its relative stability to urea and heat. Significant increase in the activity of all iso-enzyme
A study of karyotypes and neutrophil alkaline phosphatase (NAP) was carried out for 66 parents (33 couples) of trisomy 21 children and for 60 control parents (30 couples). Enzyme activity was determined simultaneously by biochemical and cytochemical techniques. In the mothers of trisomy 21 children