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Uracil phosphoribosyltransferase activity in hereditary orotic aciduria

✍ Scribed by Satoshi Sumi; Mitsuhiro Andou; Naoki Hamajima; Kiyoshi Kidouchi; Hajime Togari; Yoshiro Wada

Book ID
117075970
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
55 KB
Volume
283
Category
Article
ISSN
0009-8981

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## Abstract ## BACKGROUND 5‐Fluorouracil (5‐FU), an antitumor agent, is used clinically against a variety of malignancies, including bladder carcinoma. 5‐FU is a prodrug, and orotate phosphoribosyltransferase (OPRT) is the principal enzyme that converts 5‐FU directly into an active antitumor metab