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Uracil-based angiotensin II receptor antagonists

✍ Scribed by Dieter Dorsch; Werner W.K.R. Mederski; Mathias Osswald; Norbert Beier; Pierre Schelling

Book ID: 108038888
Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 267 KB
Volume: 5
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(95)00370-9

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## Abstract Angiotensin II (A‐II) is the main effector of the renin‐angiotensin system. A‐II functions by binding its type 1 (AT1) receptors to cause vasoconstriction and retention of sodium and fluid. Several AT1 receptor antagonists—a group of drugs collectively called “sartans”—have been markete