Uptake of MnCl2 and mangafodipir trisodium in the myocardium: A magnetic resonance imaging study in pigs

✍ Scribed by Rolf Eriksson; Lars Johansson; Tomas Bjerner; Karen Briley Saebo; Håkan Ahlström

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 167 KB
• Volume: 19
• Category: Article
• ISSN: 1053-1807
• DOI: 10.1002/jmri.20038

✦ Synopsis

Abstract

Purpose

To examine the changes in the longitudinal relaxation times (ΔR1) induced in pig myocardium and blood following injections of 5, 10, and 15 μmol mangafodipir trisodium (Mn‐DPDP) or MnCl~2~/kg of body weight (b.w.).

Materials and Methods

Twelve pigs were divided into two groups, one group receiving MnCl~2~ and the other receiving Mn‐DPDP. Three consecutive doses of contrast agent (5, 10, and 15 μmol/kg of b.w.) were injected in each animal with a 40‐minute time interval between each dose. Measurements of T~1~ in blood and myocardium were made 5, 15, 25, and 35 minutes after each injection. Additionally, relaxivity measurements in blood samples were performed.

Results

An increase in myocardial R1 was observed for both contrast agents at all concentration levels tested. This increase peaked 5 minutes after injection and then declined. An increase could still be detected 35 minutes after injection. The effect was larger when using MnCl~2~ than when using Mn‐DPDP.

Conclusion

The dissociation kinetics of Mn^2+^ from the DPDP ligand limits the relaxation increase of Mn‐DPDP relative to that of MnCl~2.~ On the other hand, the toxicity of MnCl~2~ may exclude it from clinical use. J. Magn. Reson. Imaging 2004;19:564–569. © 2004 Wiley‐Liss, Inc.