Uptake of iron from transferrin by isolated hepatocytes
β Scribed by Ketil Thorstensen; Inge Romslo
- Book ID
- 118210066
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 643 KB
- Volume
- 804
- Category
- Article
- ISSN
- 0167-4889
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π SIMILAR VOLUMES
Isolated rat hepatocytes accumulate iron from iron-transferrin by a process which is dependent on the temperature and on the transferrin concentration, and which is diminished by treatment of the cells with a proteolytic enzyme. These observations are consistent with a mechanism for iron uptake into
HFE-related hereditary hemochromatosis results in hepatic iron overload. Hepatocytes acquire transferrin-bound iron via transferrin receptor (Tfr) 1 and Tfr1-independent pathways (possibly Tfr2-mediated). In this study, the role of Hfe in the regulation of hepatic transferrin-bound iron uptake by th