Uptake of cadmium in isolated kidney cells—influence of binding form and in vivo pretreatment

✍ Scribed by Taiyi Jin; Gunnar F. Nordberg; Monica Nordberg

• Publisher: John Wiley and Sons
• Year: 1986
• Tongue: English
• Weight: 368 KB
• Volume: 6
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/jat.2550060603

✦ Synopsis

Uptake of cadmium as 109CdCl2, 109Cd-cysteine, 109Cd-albumin and 109Cd-metallothionein was studied in isolated kidney cells from rat. Cd as 109CdCl2 and 109Cd-albumin was taken up at similar rates. The uptake of cadmium as 109Cd-cysteine was greater and that of 109Cd-metallothionein lower compared with that of the other substances. These observations were made on non-pretreated cells. In cells taken from rats pretreated with CdCl2 in vivo, the uptake of cadmium as 109CdCl2, 109Cd-cysteine and 109Cd-albumin was lower than in cells from non-pretreated rats. However, the uptake of 109Cd-metallothionein was considerably enhanced in pretreated cells. In pretreated kidney cells the decreased uptake of Cd (as Cd-albumin) might be related to protection of the kidney against acute Cd toxicity and increased uptake of metallothionein-Cd might contribute to the explanation of renal damage in long-term Cd exposure.