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Uptake of 1-β-D-arabinofuranosylcytosine and prednisolone by synchronized human lymphoma cells

✍ Scribed by Persohn, Linda K. ;Drewinko, Benjamin ;Loo, Ti Li

Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
386 KB
Volume
2
Category
Article
ISSN
0098-1532

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✦ Synopsis

Abstract

The cytotoxicity of many antitumor agents exhibits cell‐cycle phase specificity. Using a human lymphoma cell line synchronized by thymidine block, we have investigated the differential uptake of radioactive 1‐β‐D‐arabinofuranosylcytosine (ara‐C) and prednisolone in various phases of the cycle. Uptake of ara‐C is highest during early S and declines steadily throughout the rest of the cycle. In comparison, prednisolone demonstrates no significant age‐dependent difference in uptake although its cytotoxicity is cell cycle sensitive.

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