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Uptake characteristics of the InsP3-sensitive and -insensitive Ca2+ pools in porcine aortic smooth-muscle cells: different Ca2+ sensitivity of the Ca2+-uptake mechanism

✍ Scribed by Ludwig Missiaen; Humbert De Smedt; Guy Droogmans; Ingrid Declerck; Lutgart Plessers; Rik Casteels

Book ID
115764388
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
444 KB
Volume
174
Category
Article
ISSN
0006-291X

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Characterization of two different Ca2+up
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We have examined the effect of the Ca2+ (Mg2+)-ATPase inhibitors thapsigargin (TG) and vanadate on ATP-dependent 45Ca2+ uptake into IP3-sensitive Ca2+ pools in isolated microsomes from rat pancreatic acinar cells. The inhibitory effect of TG was biphasic. About 40-50% of total Ca2+ uptake was inhibi