Uptake and metabolism of daunorubicin by human leukemia cells
β Scribed by Michael W. DeGregorio; Carlos J. Carrera; John C. Klock; Jordan R. Wilbur
- Publisher
- Springer
- Year
- 1982
- Tongue
- English
- Weight
- 390 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0344-5704
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π SIMILAR VOLUMES
Heterogeneity in daunorubicin uptake by leukemic blast cells obtained from the bone marrow of 16 patients with acute leukemia (10 acute nonlymphocytic leukemia and 6 acute lymphocytic leukemia) was determined by laser flow cytometry following drug treatment in vitro for 1 hr. Fluorescence profiles o
## Abstract Based on the fluorescence properties of adriamycin (ADM) and daunorubicin (DNR), uptake in sensitive and resistant Friend leukemia cells (FLC) was studied with the aid of the fluorescence activated cell sorter (FACS II). A quantitative cell by cell fluorescence intensity analysis showed
The metabolism of daunorubicin (DNR) to daunorubicinol and daunomycinone in murine leukaemia cells has been examined by means of high-performance liquid chromatography. A rapid and efficient extraction method has been developed that permits the recovery of the drug and its metabolites from cell homo