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Upregulation of secretin receptors on cholangiocytes after bile duct ligation

✍ Scribed by P.S. Tietz; E.M. Hadac; L.J. Miller; N.F. LaRusso


Book ID
117348335
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
276 KB
Volume
97
Category
Article
ISSN
0167-0115

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During bile duct ligation (BDL), the growth of large cholangiocytes is regulated by the cyclic adenosine monophosphate (cAMP)/extracellular signal-regulated kinase 1/2 (ERK1/2) pathway and is closely associated with increased secretin receptor (SR) expression. Although it has been suggested that SR