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Upregulation of phosphoinositide 3-kinase and protein kinase B in alveolar macrophages following ozone inhalation. Role of NF-κB and STAT-1 in ozone-induced nitric oxide production and toxicity

✍ Scribed by Debra L. Laskin; Ladan Fakhrzadeh; Diane E. Heck; Donald Gerecke; Jeffrey D. Laskin


Book ID
110343629
Publisher
Springer
Year
2002
Tongue
English
Weight
105 KB
Volume
234/235
Category
Article
ISSN
0300-8177

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## Abstract Expression of inducible nitric oxide synthase (iNOS), which leads to the production of nitric oxide (NO), is stimulated by proinflammatory cytokines such as interleukin‐1β (IL‐1β) and tumor necrosis factor‐α (TNF‐α). Here we report on the roles of nuclear factor‐κB (NF‐κB) and mitogen‐a