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Upregulation of PEDF by the Alzheimer's disease drug memantine is involved in the increased neurogenesis of adult mouse hippocampus

✍ Scribed by Takashi Namba; Motoko Maekawa; Takeshi Yabe; Shigeki Yuasa; Shigeo Uchino; Shinichi Kohsaka


Book ID
116776850
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
82 KB
Volume
65
Category
Article
ISSN
0168-0102

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✍ Takashi Namba; Motoko Maekawa; Shigeki Yuasa; Shinichi Kohsaka; Shigeo Uchino 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 456 KB 👁 1 views

## Abstract New neurons are continuously generated in the hippocampus of the adult mammalian brain, and __N__‐methyl‐D‐aspartate receptor (NMDA‐R) antagonists have been found to increase the number of newly generated neurons in the dentate gyrus (DG) of the adult hippocampus. In this study, we exam