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Upregulation of hepatic cholesterol 27-hydroxy-lase (CYP27) activity and normal levels of hepatic cholesterol synthesis in cholesterol 7A-hydroxylase (cyp7A1) gene knockout mice

โœ Scribed by Shefer, Sarah; Erickson, Sandra K.; Lear, Steven R.; Batta, Ashok K.; Salen, Gerald


Book ID
122769437
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
194 KB
Volume
118
Category
Article
ISSN
0016-5085

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The gene encoding cholesterol 7โฃ-hydroxylase (CYP7A1) is tightly regulated to control bile acid synthesis and maintain lipid homeostasis. Recent studies in mice suggest that bile acid synthesis is regulated by the fasted-to-fed cycle, and fasting induces CYP7A1 gene expression in parallel to the ind