Upregulation of GRP78 in Renal Cell Carcinoma and Its Significance
โ Scribed by Weijin Fu; Xiaoyun Wu; Jiachu Li; Zengnan Mo; Zhanbing Yang; Weihua Huang; Qiang Ding
- Book ID
- 116950660
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 685 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0090-4295
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## Abstract Receptorโrecognized forms of ฮฑ~2~โmacroglobulin (ฮฑ~2~M\*) bind to cell surfaceโassociated GRP78 and induce proliferative and survival signaling in prostate cancer cells. As part of the cellular response to ฮฑ~2~M\*, GRP78 expression is itself upregulated. In response to other stimuli, th
## BACKGROUND. A multiple sampling study was performed on 124 specimens of renal cell carcinomas to analyze the consistency and reliability of DNA measurements. The authors investigated intratumoral DNA heterogeneity and its role as a adverse prognostic factor for disease progression. ## METHODS