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Upregulation of DR5 by proteasome inhibitors potently sensitizes glioma cells to TRAIL-induced apoptosis

✍ Scribed by Holger Hetschko; Valerie Voss; Volker Seifert; Jochen H. M. Prehn; Donat Kögel

Book ID
111312369
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
469 KB
Volume
275
Category
Article
ISSN
1432-1327

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Quercetin sensitizes human hepatoma cells to TRAIL-induced apoptosis via Sp1-mediated DR5 up-regulation and proteasome-mediated c-FLIPS down-regulation
✍ Jin Yeop Kim; Eun Hee Kim; Seok Soon Park; Jun Hee Lim; Taeg Kyu Kwon; Kyeong So 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 460 KB

## Abstract This study demonstrates that combined treatment with subtoxic doses of quercetin (3′,3′,4′,5,7‐pentahydroxyflavone), a flavonoid found in many fruits and vegetables, plus tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) induces rapid apoptosis in TRAIL‐resistant hepatocel